Sebaceous glands are located alongside hair follicles and produce sebum (the body’s natural oil). Sebum is deposited into the canal of the hair follicle from which it then flows onto the skin serving as the body’s skin moisturizer. Acne is a disease of hair follicles manifesting in comedones, inflamed pimples, increased sebum production, higher inflammation, cell death creating plugs at the hair follicle exit, and overgrowth by virulent Cutibacterium acnes bacteria inside the hair follicle. Acne, however, is generally not believed to simply be a disease of the skin. Like many health issues, acne has its origins in the health of the gut microbiome.

The gut-skin axis has been studied extensively, showing that numerous skin diseases are associated with an altered gut microbiome. The human gut barrier regulates uptake of fluid, electrolytes, and nutrients, and prevents the penetration of pathogens. Gastrointestinal dysfunction and imbalance of the intestinal microbiome, known as dysbiosis, causes excess growth of pathogenic bacteria. This results in local and systemic inflammation that affects skin physiology.

Therefore, the most comprehensive way to treat acne is by addressing the issues affecting both the skin and gut. SKINDUO addresses both issues by combining:

• A probiotic serum (TheBioArte) that contains live lactobacilli (Lactobacillus plantarum), which helps to reduce inflammation, balance the skin microbiome, and clear the skin

• A novel gut probiotic supplement (Codex Labs) that helps to reduce gut inflammation, strengthen the gut barrier, and reduce general inflammation in the body

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